The activity of superoxide dismutase, glutathione peroxidase, and catalase was lower in the. Pdf in vitro antioxidant and antiradical properties of. Antioxidant efficacy and the upregulation of nrf2mediated. Sod, cat activities and protein levels were measured to investigate the antioxidative effect of lcarnitine on h 2 o 2damaged hl7702 cells. Effect of lcarnitine on brain lipid peroxidation and. Antiradical activity depended on the presence of a flavonol structure or free hydroxyl group at the c4 position. Lcarnitine plays an important regulatory role in the mitochondrial transport of longchain free fatty acids. This study was conducted to assess the effects of lcarnitine on antioxidant enzymes in rats fed cholesterol rich diet. Antioxidant activity, radical scavenging, structureactivity insight, taxifolin. Animals of the first group were fed standard rat pellets, animals of the second group were fed standard rat pellets that contained 7. Antioxidant potentials on these plant part extracts were assessed by the dpph free radical scavenging activity.
The present study was designed to investigate the antioxidant property of lcarnitine lc on serum levels of folliclestimulating hormone fsh. Atatrk university, faculty of arts and sciences, department of chemistry, tr erzurum. L carnitine has indispensable functions in intermediary metabolism and is received by endogenous synthesis and from exogenous sources. In vitro antioxidant and antiradical properties of hippophae rhamnoides l. Alcohol metabolism is accompanied by enhanced free radical formation and a decrease in antioxidant abilities.
Prevention by lcarnitine of dna damage induced by propionic and lmethylmalonic acids in human peripheral leukocytes in vitro. An intact lcarnitine system, with adequate amounts of lcarnitine, carnitine transferase enzymes, and carnitine derivatives, is necessary for glucose and lipid metabolism in cells and is an indication of cellular resistance to toxic effects. The present study was designed to investigate the antioxidant property of l carnitine lc on serum levels of folliclestimulating hormone fsh, luteinizing hormone lh, testosterone th and tes. Car supplementation to improve muscular performance is based on the role of l. Molecules free fulltext antioxidant activities and. Antioxidant and antiradical properties of selected flavonoids. Excessive oxidative stress and lipid peroxidation have been demonstrated to play important roles in the production of liver damage. The targeting of nutraceutical treatment to skeletal muscle damage is an emerging area of research, driven by the need for new therapies for a range of muscleassociated diseases. We evaluated the effects of carnitine on renal nonenzymatic antioxidants in young rats submitted to exhaustive exercise stress.
Molecular mechanisms and practical applications abstract during last decades there has been a growing interest in the potential uses of lcarnitine lc as a medicinal agent as well as a nutritionaldietary supplement. Urine concentrations of lc, alc and plc were detected by hplc. Jun 21, 2019 canon jx300 manual pdf using tam mode faxjxjx only. In the present study, the antioxidant properties of ltyrosine as a monophenolic and ldopa as a diphenolic amino acid were investigated by using different antioxidant assays. The radioprotectivity of lcarnitine is derived from its antioxidant effects. The effect of lcarnitine on lipid peroxidation and enzymatic antioxidants, such as.
Effects of lcarnitine on the folliclestimulating hormone. Benefits of acetyl lcarnitine antioxidant weight loss drug. Water and ethanol extracts of broccoli brassica oleracea l. In mammalian cells and body fluids, carnitine is present either as free. Article pdf available in pharmacognosy magazine 419. Evaluation of the antioxidant activity of coreopsis. Settings and whatsoever without expressed written permission from canon inc. It has the powerful antioxidant activity within carotenoids and is an effective free radical scavenger. The antioxidant activity of coffee, tea, cocoa, and red wine is compared. The reducing powers, the 2,2diphenyl1picrylhydrazyl dpph scavenging activities, the amount of total phenolic compounds, the inhibitory effect on fecl2h2o2 fenton reaction systeminduced dna damage, and the inhibitory effect on. The correlations between the levels of lcarnitine, oxidative stress, and antioxidant enzymes activities after supplementation are shown in table 3.
Antioxidant and antiradical properties of selected. Plumbagin and its cu ii complex cu plumbagin2h2o have been synthesized, and their antioxidant activities towards the inhibitory effect on dpph free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated. The current study analyzes the free radical scavenging action of lcarnitine in various brain regions of young and old rats. The model group was continued on the hfd for 6 wk as before, and the ly groups were administered orally and continued on the hfd hepatoprotextive 6 wk as before. Antioxidant and antiradical activities of flavonoids. Carnitine supplementation effects on nonenzymatic antioxidan.
From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the c3 position of the flavonoid skeleton showed high inhibitory activity to. In this study, the antioxidant activity of lcarnitine was. Gulcin i 2006 antioxidant and antiradical activities of lcarnitine. Although carnitine can be synthesized in the body, adults normally obtain carnitine from the diet. In this study, the antioxidant activity of lcarnitine was investigated as in vitro. Recently, there has been growing interest in research into the role of plantderived antioxidants in food and human health. Nov 12, 2010 alcohol metabolism is accompanied by enhanced free radical formation and a decrease in antioxidant abilities. Lcarnitine has indispensable functions in intermediary metabolism and is received by endogenous synthesis and from exogenous sources. Jarrow formulas acetyl lcarnitine 250 mg, antioxidant. Higher oxidative stress may contribute to the pathogenesis of coronary artery disease cad. Lcarnitine also helps the body function by assisting in the removal of toxic compounds from the cells. Effects of lcarnitine against oxidative stress in human hepatocytes.
Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Antioxidant activities of carotenes and xanthophylls. Studies have suggested that oxidative stress may contribute to the pathogenesis of mental disorders. Lcarnitine is a natural substance and acts as a carrier for fatty acids across the inner mitochondrial membrane for subsequent betaoxidation.
The relative importance of the antioxidant and prooxidant activities of antioxidants is an area of current research, but vitamin c, which exerts its effects as a vitamin by oxidizing polypeptides, appears to have a mostly antioxidant action in the human body. The antioxidant properties of carnitine in vitro in. However, antioxidant supplement therapy effects on reactive oxygen substances are conflicting. Canon jx300 manual pdf using tam mode faxjxjx only. Nov 20, 2011 recently, there has been growing interest in research into the role of plantderived antioxidants in food and human health. Antioxidant activities of plumbagin and its cu ii complex.
All studied ethanolic extracts exhibited considerable activity to scavenge dpph and hydroxyl free radicals, reducing power, iron chelating. Comparison of in vitro antioxidant and antiradical. In this study, the antioxidant activity of the lcarnitine was compared to. Effects of lcarnitine against oxidative stress in human. Antioxidant activities of three selected micromeria species growing in croatia m. It has also been reported that several ros are released during such inflammation 22.
Apr 01, 2002 matsuoka and coworkers reported that, in the mouse, l carnitine suppressed seizures and impairments of brain metabolism caused by hyperammonemia. Lcarnitine has a protective effect on the colonic mucosa. Antioxidant and antiradical activities of lcarnitine, life sci. The aim of the present study was to determine the antioxidant activity of coreopsis tinctoria flowering tops ctft. In this context, molecules with antioxidant activity may be promising agents in the treatment of these deleterious conditions. Oct 25, 2019 it has the powerful antioxidant activity within carotenoids and is an effective free radical scavenger. The beneficial influence of many foodstuffs and beverages including fruits, vegetables, tea, coffee, and cacao on human health has been recently recognized to originate from their antioxidant activity. Antioxidant and antiradical activities of lcarnitine pdf download. There are many benefits of acetyl l carnitine, however more research is required to support them. Read l carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders, gene on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Ms analysis, antioxidant and anticholinergic properties of galanga alpinia officinarum hance rhizomes industrial crops and products 74 2015 712721 contents lists available at sciencedirect industrial crops and products journal homepage. Cardiovascular disease is the leading cause of death worldwide. Free radical scavenging and antiacetylcholinesterase. Urine concentrations of lc, alc and plc were detected by.
Jan 10, 2014 read l carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders, gene on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. However, lcarnitine appears to have antioxidant properties and the ability to regulate ethanol metabolism. While the antioxidative properties of green and black tea have been extensively studied, less attention has been given to these properties in oolong tea. Free download full movie gandhi my father 3 mp4 movies. Lcarnitine carn is an essential nutrient and plays a key role in mitochondrial. Effects of lcarnitine in the distillers dried grains with. A croatian indigenous cultivar of lavandin, lavandula x intermedia budrovka lamiaceae was studied for the phenolic acids, flavonoids, anthocyanins, procyanidins and total tannins, as well as total polyphenols content, in the flower, inflorescence stalk and leaf ethanolic extracts. Also lcarnitine promoted endogenous antioxidant defense components including total antioxidative capacity, glutathione. Oct 09, 2002 while the antioxidative properties of green and black tea have been extensively studied, less attention has been given to these properties in oolong tea.
Antioxidant activities of carnitine in physiologically relevant concentrations have been well demonstrated in various in vitro systems including cell cultures or isolated cells or organelles. Antioxidant, free radical scavenging activities and total polyphenolic content of aqueous extracts from seven blueberry cultivars grown in new zealand abstract antioxidant activity in blueberries or other fruits is an appealing characteristic to consumers and food industries. As a dietary supplement to improve athletic performance, carn has. Protective effect of lc and its derivatives on the antioxidant systems of the body are also shown in various models of oxidative stresstoxicity caused by a variety of toxicants and neurotoxic agents. Therefore, antioxidant with free radical scavenging activities may have great relevance in the prevention and therapeutics of diseases in which oxidants or free radicals are implicated 24. Lcarnitine plays an important regulatory role in the. The aim of this study was to investigate whether the protective effect of l carnitine was associated with the nuclear factor erythroid 2 nfe2related factor 2 nrf 2 pathway. Antioxidant and antiradical activities of wu ling shen in a cell free system. It plays an obligate role in fatty acid metabolism by directing fatty acids into the mitochondrial oxidative pathway through the action of.
The antioxidant properties of the lcarnitine were evaluated by using different antioxidant assays such as 1, 1diphenyl2picrylhydrazyl free radical dpph scavenging, total antioxidant activity, reducing power, superoxide anion radical scavenging, hydrogen peroxide scavenging and metal chelating activities. The activity of superoxide dismutase, glutathione peroxidase, and. The purpose of this study was to investigate the effect of lcarnitine lc, mgd on the markers of oxidative stress and antioxidant enzymes activities in cad patients. After 12 weeks of supplementation, the level of lc was significantly correlated with the antioxidant enzymes activities cat. Lcarnitine amino acidantioxidant injectable lcarnitine is a powerful antioxidant. Due to the harmful effects of synthetic antioxidants such as bha and bht, natural novel antioxidants have become the focus of attention for protecting foods and beverages and reducing oxidative stress in vivo. Acetyllcarnitine alc is a multitarget molecule that modulates the uptake of acetylcoa into the mitochondria during fatty acid oxidation, acetylcholine production. Potential therapeutic role of lcarnitine in skeletal muscle. Evaluation of the antioxidant activity of coreopsis tinctoria. Antioxidant effect of lcarnitine in rats fed cholesterol. Antioxidant and antiradical activities of lcarnitine request pdf. Effect of lcarnitine on dna damage and oxidative stress in.
Lcarnitine prevents free radical formation by both inhibiting enzymesynthesis and activity and also inducing antioxidant mechanisms. Data on the antiradical activity of coffee is provided. If the inline pdf is not rendering correctly, you can download the pdf file here. Mar 21, 2012 l carnitine is a natural substance and acts as a carrier for fatty acids across the inner mitochondrial membrane for subsequent betaoxidation.
Pbs to make them lcarnitine free and then cells in fresh medium. The effect of lcarnitine on lipid peroxidation and enzymatic antioxidants, such as superoxide dismutase, catalase, and glutathione peroxidase, was evaluated in brain regions of young and old rats. The radioprotectivity of l carnitine is derived from its antioxidant effects. The antiradical activity characterizes the ability of components to react with free radicals in a single free radicals reaction, but antioxidant activity represents the ability to inhibit the process of oxidation which usually involves a set of different reactions.
Antioxidants fight harmful particles in the body known as free radicals, which damage cells and tamper with dna. Pdf prevention by lcarnitine of dna damage induced by. It is also an antioxidant that reduces metabolic stress in the cells. Lcarnitine lc is a naturally occurring and widely distributed in nature compound. The antioxidant properties of the lcarnitine were evaluated by using different antioxidant assays such as 1, 1diphenyl2picrylhydrazyl free radical dpph scavenging, total antioxidant activity.
These findings suggested that l carnitine might modulate energy metabolism in the brain. Lcarnitine promoted endogenous antioxidant defense in hl7702 cells under oxidative stress. Coa, an intermediate product of the krebs cycle which is thereby stimulated. The present study was designed to estimate the effect of lcarnitine on the antioxidant capacity of the rat brain and blood serum. Potential therapeutic role of lcarnitine in skeletal. The activity was expressed as umg protein in cells. The urine excretion of lcarnitine lc, acetyllcarnitine alc and propionyl lcarnitine plc and their relations with the antioxidant activities are presently unknown. Antioxidant and antiradical activities of lcarnitine. Comparison is carried out of the aa of coffee arabica and coffee robusta roasted at different temperatures as well as by different roasting methods microwave, convection, etc. Ms analysis, antioxidant and anticholinergic properties of. Antioxidant, free radical scavenging activities and total.
A total of 32 healthy male wistar albino rats were allocated to four groups. Phenolic compounds are interesting because of their antioxidant properties. The antioxidant effect of lcarnitine may be partially due to. For this purpose, the most commonly methods used in vitro. Anxiolytic and antistress effects of acute administration. The american journal of chinese medicine 2009, 37 04, 815828. Since antioxidant capacity is directly correlated with their reducing capacity, both frap and cuprac assays provide a reliable method for the evaluation of antioxidant activities of various plant. Acetyl l carnitine can act as an antioxidant and may interact with certain other drugs, enhancing their effectiveness or reducing their side effects.
Jinlian li, a b yanli zhang, b haiyun luan, b xuehong chen, c yantao han, c chunbo wang c a medical college, qingdao university, 308 ningxia road, qingdao 266071, china. An intact l carnitine system, with adequate amounts of l carnitine, carnitine transferase enzymes, and carnitine derivatives, is necessary for glucose and lipid metabolism in cells and is an indication of cellular resistance to toxic effects. Effects of l carnitine in the distillers dried grains with solubles diet of sows on reproductive performance and antioxidant status of sows and their offspring volume issue 7 b. As a dietary supplement to improve athletic performance. Studies were conducted to obtain suitable extraction conditions for chlorogenic acid, quercetin, luteolin, apigenin and kaempferol, which were identified and quantified by hplc. The antioxidant properties of the lcarnitine were evaluated by using different antioxidant assays such as 1, 1diphenyl2picrylhydrazyl free radical dpph. It plays an obligate role in fatty acid metabolism by directing fatty acids into the mitochondrial oxidative pathway through the action of specialised acyltransferases. Effect of lcarnitine on brain lipid peroxidation and antioxidant. Jan 18, 2006 antioxidant and antiradical activities of lcarnitine. Effects of lcarnitine supplementation on oxidative stress. In our previous study, l carnitine was shown to have cytoprotective effect against hydrogen peroxide h 2 o 2induced injury in human normal hl7702 hepatocytes. The role of carnitine in male infertility mongioi 2016.
Effects of lcarnitine in the distillers dried grains with solubles diet of sows on reproductive performance and antioxidant status of sows and their offspring volume issue 7 b. Oct 01, 2008 read effect of dietary supplemental l. Lcarnitine and its functional effects in poultry nutrition. A free radical can be described as a molecule or molecular fragment. Aurelia magdalena pisoschi, carmen cimpeanu, gabriel.
310 1245 138 901 1343 21 454 1371 234 1539 223 1322 566 1430 1022 387 312 1280 786 93 1437 991 1058 807 135 1077 780 1252 762 880 1093 302 29 1182 1428